![]() ![]() ![]() Failure of neuronal homeostasis results in common neuropsychiatric phenotypes. From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome. The autistic neuron: troubled translation? Cell 135, 401–406 (2008).īagni, C. Dendritic anomalies in disorders associated with mental retardation. Swanson) (OxfordUniversityPress,NewYork, 1995). Histology of the Nervous System of Man and Vertebrate. This is controlled by the microRNA bantam in epithelial cells, which signals to adjacent neurons.ĭefects in dendrite morphogenesis might contribute to mental disorders such as schizophrenia and autism. In Drosophila melanogaster, dendrite expansion in sensory neurons is scaled to precisely match the growing epidermis. They in turn are regulated by the tumour suppressor Hippo. Tiling and dendrite maintenance can be differentially regulated by the NDR (nuclear DBF2-related) kinase family members Tricornered and Warts, respectively. Mechanisms such as differential reliance on the secretory pathway contribute to the differentiation of axons and dendrites.Ī number of transcription factors confer neurons with distinctive dendrite morphologies.ĭown syndrome cell adhesion molecule (DSCAM) has an evolutionarily conserved role in mediating self-avoidance of dendrites such that the dendrites of each neuron can spread out.Ĭertain types of neurons exhibit homotypic repulsion of their dendrites to allow tiling of their dendritic fields for maximal coverage without ambiguity. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |